Synthesis and identification of conformationally constrained selective MMP inhibitors

Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. doi: 10.1016/s0960-894x(99)00285-1.

Abstract

We have discovered a new series of potent conformationally constrained MMP Inhibitors that are selective for MMP-13 over MMP-1.

MeSH terms

  • Collagenases / metabolism
  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry*
  • Inhibitory Concentration 50
  • Matrix Metalloproteinase 1
  • Matrix Metalloproteinase 13
  • Matrix Metalloproteinase 8
  • Matrix Metalloproteinase Inhibitors
  • Metalloendopeptidases / antagonists & inhibitors*
  • Metalloendopeptidases / chemistry*
  • Models, Chemical
  • Models, Molecular

Substances

  • Enzyme Inhibitors
  • Matrix Metalloproteinase Inhibitors
  • Collagenases
  • Matrix Metalloproteinase 13
  • Metalloendopeptidases
  • Matrix Metalloproteinase 8
  • Matrix Metalloproteinase 1